Vector Labs Ab03653-10.0 Anti-IL-1B [MAb201], Human IgG1, kappa (100 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: MAb201
Synonyms: IL1B; IL-1β; 1L1F2; Interleukin-1 beta; IL-1 beta; Catabolin
Amount: 100 μg
Application Codes Clone: WB; ICC; neutralize; inhibit
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds human Interleukin-1 beta, which is a potent pro-inflammatory cytokine. This antibody is reported to show some cross reactivity with recombinant mouse IL-1b. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. It promotes Th17 differentiation of T-cells and synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. It also plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6.
Application Notes: This antibody can be used in the detection of human IL-1b using western blot (PMID: 19465481). This antibody was used for the immunocytochemical staining of nuclear IL-1b in human breast cancer samples (PMID: 21057224). This antibody has been reported to neutralize the human IL-1 beta induced stimulation of proliferation in the D10.G4.1 mouse helper T cell line in a dose-dependent manner. This antibody inhibits binding of IL-1RAcP to IL-1 bound IL-1R1. This antibody is also reported to be as potent as IL-1ra in inhibiting IL-1 induced IL-6 in human chondrocytes. (US20030026806). Humanized version of this antibody is available on request.

Product Class:	Purified
Clone ID:	MAb201
Synonyms:	IL1B; IL-1β; 1L1F2; Interleukin-1 beta; IL-1 beta; Catabolin
Amount:	100 μg
Application Codes Clone:	WB; ICC; neutralize; inhibit
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds human Interleukin-1 beta, which is a potent pro-inflammatory cytokine. This antibody is reported to show some cross reactivity with recombinant mouse IL-1b. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. It promotes Th17 differentiation of T-cells and synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. It also plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6.
Application Notes:	This antibody can be used in the detection of human IL-1b using western blot (PMID: 19465481). This antibody was used for the immunocytochemical staining of nuclear IL-1b in human breast cancer samples (PMID: 21057224). This antibody has been reported to neutralize the human IL-1 beta induced stimulation of proliferation in the D10.G4.1 mouse helper T cell line in a dose-dependent manner. This antibody inhibits binding of IL-1RAcP to IL-1 bound IL-1R1. This antibody is also reported to be as potent as IL-1ra in inhibiting IL-1 induced IL-6 in human chondrocytes. (US20030026806). Humanized version of this antibody is available on request.

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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