Mfg Part Number
Ab03654-10.0
Vector Labs Ab03654-10.0 Anti-IL-1B [IC8], Human IgG1, kappa (100 μg)
Quick Overview
The original mouse antibody was generated by immunizing mice with human IL-1B protein. The humanized version was generated by grafting CDRs of the original mouse antibody onto human framework regions.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | IC8 |
| Synonyms: | IL1B; IL-1β; 1L1F2; Interleukin-1 beta; IL-1 beta; Catabolin; 1C8 |
| Amount: | 100 μg |
| Application Codes Clone: | neutralize |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds human Interleukin-1 beta, which is a potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. It promotes Th17 differentiation of T-cells and synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. It also plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. |
| Application Notes: | This antibody is the humanized version of original mouse antibody IC8. This antibody binds human IL-1B with a binding affinity of Kd= 0.28 nM. The Fab version of this antibody was reported to neutralize IL-1B activity both in an in vitro and an in vivo assay (US7608694). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |