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Mfg Part Number

Ab03656-23.0

Vector Labs Ab03656-23.0 Anti-HLA-G [YWHG-5], Rabbit IgG, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing BALB/c mice with synthetic human HLA-G molecule heavy chain α3 structural domain and HLA-G5/6 molecule specific transmembrane region amino acid sequence 'EGLPEPLMLRWSKEGDGGIMS'.

$570.70

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Description

Product Class: Purified
Clone ID: YWHG-5
Synonyms: HLAG; HLA-6.0; HLA class I histocompatibility antigen alpha chain G; HLA G antigen; MHC class I antigen G
Amount: 100 μg
Application Codes Clone: ELISA; WB; FC; IHC
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody specifically binds the amino acid sequence 'EGLPEPLMLRWSKEGDGGIMS' in the α3 structural domain of the human HLA-G5 and HLA-G6. HLA-G5 and HLA-G6 are secreted forms of HLA-G that are non-classical major histocompatibility class Ib molecules involved in immune regulatory processes at the maternal-fetal interface. HLA-G expression has been reported in numerous types of cancer, always associated with more advanced stage and aggressive development of the tumor.
Application Notes: This antibody can bind human HLA-G peptide 'EGLPEPLMLRWSKEGDGGIMS' in an ELISA with a binding affinity of Ka= 1.01 X 10^(9) L/mol. This antibody was capable of detecting G5 and G6 isoforms of human HLA-G in a western blot and does not cross react with any other isoforms of HLA-G. This antibody was also used in the detection of soluble HLA-G5 and HLA-G6 using intracellular flow cytometry of K562-HLA-G5 and K562-HLA-G6 cells. This antibody can also be used for the immunohistochemical staining of HLA-G5/6 molecular expression in gastric cancer tissue using immunohistochemistry (CN114605543).

Product Class:	Purified
Clone ID:	YWHG-5
Synonyms:	HLAG; HLA-6.0; HLA class I histocompatibility antigen alpha chain G; HLA G antigen; MHC class I antigen G
Amount:	100 μg
Application Codes Clone:	ELISA; WB; FC; IHC
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody specifically binds the amino acid sequence 'EGLPEPLMLRWSKEGDGGIMS' in the α3 structural domain of the human HLA-G5 and HLA-G6. HLA-G5 and HLA-G6 are secreted forms of HLA-G that are non-classical major histocompatibility class Ib molecules involved in immune regulatory processes at the maternal-fetal interface. HLA-G expression has been reported in numerous types of cancer, always associated with more advanced stage and aggressive development of the tumor.
Application Notes:	This antibody can bind human HLA-G peptide 'EGLPEPLMLRWSKEGDGGIMS' in an ELISA with a binding affinity of Ka= 1.01 X 10^(9) L/mol. This antibody was capable of detecting G5 and G6 isoforms of human HLA-G in a western blot and does not cross react with any other isoforms of HLA-G. This antibody was also used in the detection of soluble HLA-G5 and HLA-G6 using intracellular flow cytometry of K562-HLA-G5 and K562-HLA-G6 cells. This antibody can also be used for the immunohistochemical staining of HLA-G5/6 molecular expression in gastric cancer tissue using immunohistochemistry (CN114605543).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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