Mfg Part Number
Ab03674-23.0
Vector Labs Ab03674-23.0 Anti-Junin virus GP1 [CR1-10], Rabbit IgG, kappa (100 μg)
Quick Overview
The original antibody was isolated from the peripheral blood lymphocytes of a human patient who had been immunized with Candid#1 2 years prior to sampling. Candid#1 is a live attenuated JUNV vaccine.
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| Product Class: | Purified |
|---|---|
| Clone ID: | CR1-10 |
| Synonyms: | JUNV GP1; GPC; Glycoprotein G1; Pre-glycoprotein polyprotein GP complex; Pre-GP-C; Argentinian mammarenavirus |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; neutralization |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds the GP1 subunit of their envelope glycoprotein of Junin virus (JUNV). This antibody does not bind the TfR1 receptor binding site in GP1. Junin virus also known as Argentinian mammarenavirus is an arenavirus in the Mammarenavirus genus which causes Argentine Haemorrhagic Fever (AHF). Mammarenaviruses sporadically cause zoonotic infections in humans, which may lead to life-threatening viral haemorrhagic fever (VHF) disease. VHFs caused by arenaviruses are acute diseases with considerable mortality rates. Symptoms are fever, malaise, headache, nausea, diarrhea, petechial hemorrhage of the soft tissues, lethargy, and irritability. Members of the Arenaviridae family are enveloped viruses with a bi-partite RNA genome coding for four viral proteins. The virus is spread through the aerosolization of host rodent excreta. |
| Application Notes: | This antibody is capable of binding Junin virus GP1 and GP1 mutant by ELISA. The Fab version of this antibody binds JUNV GP1 with a binding affinity of Kd=25nM. This antibody shows mild neutralization of JUNV (PMID: 29760382). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |