Mfg Part Number
Ab03688-23.0
Vector Labs Ab03688-23.0 Anti-CD19 [1D3], Rabbit IgG, kappa (100 μg)
Quick Overview
Vector Labs Ab03688-23.0 Anti-CD19 [1D3], Rabbit IgG, kappa (100 μg)
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | 1D3 |
| Synonyms: | B-lymphocyte antigen CD19; Differentiation antigen CD19 |
| Amount: | 100 μg |
| Application Codes Clone: | FC; |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody is specific for mouse CD19. |
| Application Notes: | The scFv fragment of the antibody was employed in the generation of a chimeric antigen receptor (CAR) which bound to CD19. Mice were administered mouse CAR-expressing cells or control cells. Anti-muCD19 CAR-T mice exhibited elevated serum IL-6 levels on day 2 after CAR-T administration, with a decrease at day 5, compared to control mice that exhibited very low or no increase in serum IL-6 levels. A20 tumor bearing mice were administered CPA and anti -mouse CD 19 CAR-T cells and evaluated for various parameters. Animals treated with CPA and anti-mouse CD 19 CAR-T cells were observed to have elevated levels of serum cytokines, as compared to controls (EP3644721A1). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |