Vector Labs Ab03700-3.0 Anti-GDF15 [Clone 29], Mouse IgG2b, kappa (100 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: Clone 29
Synonyms: MIC-1; GDF-15 MIC1; PDF; PLAB; PTGFB; NAG-1; NRG-1; NAG1; NRG1; Growth/differentiation factor 15; growth and differentiation factor 15; Macrophage inhibitory cytokine 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor; Clone#29; #29
Amount: 100 μg
Application Codes Clone: ELISA; WB; inhibit; functional assay
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds the human growth/differentiation factor 15 (GDF-15) also known as macrophage inhibitory cytokine 1. GDF-15 is a divergent member of the transforming growth factor-β (TGF-β) superfamily. While physiological expression is barely detectable in most somatic tissues in humans, GDF-15 is abundant in placenta. It regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Highly elevated GDF-15 levels are mostly linked to pathological conditions including inflammation, myocardial ischemia, and notably cancer. GDF-15 is widely explored as a biomarker for disease prognosis.
Application Notes: This antibody can detect human GDF-15 protein in an ELISA and western blot. This antibody significantly reduces the neovascularization of endothelial cells produced by the GDF-15 protein. It also inhibits the growth of skin cancer, colon cancer, breast cancer or prostate cancer, pancreatic cancer, liver cancer, gastric cancer, inhibits angiogenesis inside/outside these tissues and inhibits the proliferation of cancer cells. The angiogenesis inhibitory activity was first confirmed in vitro through the tube formation assay and aortic ring branching assay. The inhibitory activity of this antibody was also tested in an in vivo angiogenesis assay using chick chorioallantoic membrane (CAM). It was reported that this antibody can inhibit angiogenesis in vivo to an excellent degree. This antibody is recommended for diagnosis of disease where GDF-15 is overexpressed (WO2019004550).

Product Class:	Purified
Clone ID:	Clone 29
Synonyms:	MIC-1; GDF-15 MIC1; PDF; PLAB; PTGFB; NAG-1; NRG-1; NAG1; NRG1; Growth/differentiation factor 15; growth and differentiation factor 15; Macrophage inhibitory cytokine 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor; Clone#29; #29
Amount:	100 μg
Application Codes Clone:	ELISA; WB; inhibit; functional assay
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds the human growth/differentiation factor 15 (GDF-15) also known as macrophage inhibitory cytokine 1. GDF-15 is a divergent member of the transforming growth factor-β (TGF-β) superfamily. While physiological expression is barely detectable in most somatic tissues in humans, GDF-15 is abundant in placenta. It regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Highly elevated GDF-15 levels are mostly linked to pathological conditions including inflammation, myocardial ischemia, and notably cancer. GDF-15 is widely explored as a biomarker for disease prognosis.
Application Notes:	This antibody can detect human GDF-15 protein in an ELISA and western blot. This antibody significantly reduces the neovascularization of endothelial cells produced by the GDF-15 protein. It also inhibits the growth of skin cancer, colon cancer, breast cancer or prostate cancer, pancreatic cancer, liver cancer, gastric cancer, inhibits angiogenesis inside/outside these tissues and inhibits the proliferation of cancer cells. The angiogenesis inhibitory activity was first confirmed in vitro through the tube formation assay and aortic ring branching assay. The inhibitory activity of this antibody was also tested in an in vivo angiogenesis assay using chick chorioallantoic membrane (CAM). It was reported that this antibody can inhibit angiogenesis in vivo to an excellent degree. This antibody is recommended for diagnosis of disease where GDF-15 is overexpressed (WO2019004550).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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