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Mfg Part Number

Ab03701-23.0

Vector Labs Ab03701-23.0 Anti-GDF15 [MBM-12], Rabbit IgG, kappa (100 μg)

VECTOR LABS

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Quick Overview

This antibody was isolated from a human single chain Fv (scFv) phage library using phage display technology. The library was generated from the mRNA obtained from the spleen of an immunized mouse injected with recombinant human GDF-15 protein.

$570.70

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Description

Product Class: Purified
Clone ID: MBM-12
Synonyms: MIC-1; GDF-15 MIC1; PDF; PLAB; PTGFB; NAG-1; NRG-1; NAG1; NRG1; Growth/differentiation factor 15; growth and differentiation factor 15; Macrophage inhibitory cytokine 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor
Amount: 100 μg
Application Codes Clone: ELISA; inhibit; functional assay
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: scFv
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds the human growth/differentiation factor 15 (GDF-15) also known as macrophage inhibitory cytokine 1. GDF-15 is a divergent member of the transforming growth factor-β (TGF-β) superfamily. While physiological expression is barely detectable in most somatic tissues in humans, GDF-15 is abundant in placenta. It regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Highly elevated GDF-15 levels are mostly linked to pathological conditions including inflammation, myocardial ischemia, and notably cancer. GDF-15 is widely explored as a biomarker for disease prognosis.
Application Notes: The binding characterization of this antibody was done using ELISA. This antibody was reported to inhibit tube formation of HUVEC cells and branching of arterial sections. This antibody can effectively block the angiogenesis-inducing function of MIC-1 (KR101346181).

Product Class:	Purified
Clone ID:	MBM-12
Synonyms:	MIC-1; GDF-15 MIC1; PDF; PLAB; PTGFB; NAG-1; NRG-1; NAG1; NRG1; Growth/differentiation factor 15; growth and differentiation factor 15; Macrophage inhibitory cytokine 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor
Amount:	100 μg
Application Codes Clone:	ELISA; inhibit; functional assay
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	scFv
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds the human growth/differentiation factor 15 (GDF-15) also known as macrophage inhibitory cytokine 1. GDF-15 is a divergent member of the transforming growth factor-β (TGF-β) superfamily. While physiological expression is barely detectable in most somatic tissues in humans, GDF-15 is abundant in placenta. It regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Highly elevated GDF-15 levels are mostly linked to pathological conditions including inflammation, myocardial ischemia, and notably cancer. GDF-15 is widely explored as a biomarker for disease prognosis.
Application Notes:	The binding characterization of this antibody was done using ELISA. This antibody was reported to inhibit tube formation of HUVEC cells and branching of arterial sections. This antibody can effectively block the angiogenesis-inducing function of MIC-1 (KR101346181).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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