Mfg Part Number
Ab03715-10.3
Vector Labs Ab03715-10.3 Anti-IL-4 [25D2-9], Human IgG1, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing Lewis rat with 1ml of human IL-4. The humanized version of the antibody was created later by grafting CDRs from the original rat antibody onto human framework regions.
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| Product Class: | Purified |
|---|---|
| Clone ID: | 25D2-9 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | IL4; BSF-1; Interleukin-4; B-cell stimulatory factor 1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra; MP4.25D2.11; ATCC HB 9809 |
| Amount: | 100 μg |
| Application Codes Clone: | inhibit; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds human IL-4. Interleukin-4 is a cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. It induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. It also induces expression of class II MHC molecules on resting B-cells and enhances both secretion and cell surface expression of IgE and IgG1. |
| Application Notes: | The binding characterization of this antibody for human IL-4 was done using ELISA. This antibody was also capable of inhibiting binding of radiolabeled hIL-4 to recombinant hIL-4 receptors expressed on the Jijoye CJ cell line. This antibody was also reported to inhibit induction of human growth hormone in the germline epsilon reporter assay (US5597710; US5863537). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |