Vector Labs Ab03739-10.0 Anti-CD155 [SKII.4], Human IgG1, kappa (100 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: SKII.4
Synonyms: PVR; PVS; NECL-5; Poliovirus receptor; Nectin-like protein 5
Amount: 100 μg
Application Codes Clone: ICC; IHC; ELISA; FC; IF; IP
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds an epitope in the extracellular region human CD155 also called the poliovirus receptor (PVR). This protein mediates NK cell adhesion and triggers NK cell function. It also binds two NK cell receptors CD96 and CD226. CD155 is gaining more interest as a therapeutic target in the field of tumor immunology due to its prominent endogenous and immune functions.
Application Notes: This antibody was used in staining of Daudi-PVR cells and the visualization of its interaction between NK92 using confocal microscopy (PMID: 15034010). This antibody was used in the immunohistochemical staining of cryostat sections of frozen specimens of human lymph nodes and spleen tissues. This antibody was also capable on blocking the interaction between soluble form of PVR (PVR-hFc) and WUCAM/Baf3 cells (PMID: 19197944). The biotinylated antibody can be used for the detection of soluble PVR-hFc in an ELISA (PMID: 20201043). The upregulation of PVR (CD155) in Jurkat cells, when transduced with WPI or HIV-1 NL4-3 strain (VprWT) lentivirus was studied using flow cytometry (PMID: 24045107). This antibody was used for identification of surface expression of DNAM1 ligands on MM cell lines by immunofluorescence staining. This antibody was also used of the immunoprecipitation of CD155 from ARK cell lysates (PMID: 28874810).

Product Class:	Purified
Clone ID:	SKII.4
Synonyms:	PVR; PVS; NECL-5; Poliovirus receptor; Nectin-like protein 5
Amount:	100 μg
Application Codes Clone:	ICC; IHC; ELISA; FC; IF; IP
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds an epitope in the extracellular region human CD155 also called the poliovirus receptor (PVR). This protein mediates NK cell adhesion and triggers NK cell function. It also binds two NK cell receptors CD96 and CD226. CD155 is gaining more interest as a therapeutic target in the field of tumor immunology due to its prominent endogenous and immune functions.
Application Notes:	This antibody was used in staining of Daudi-PVR cells and the visualization of its interaction between NK92 using confocal microscopy (PMID: 15034010). This antibody was used in the immunohistochemical staining of cryostat sections of frozen specimens of human lymph nodes and spleen tissues. This antibody was also capable on blocking the interaction between soluble form of PVR (PVR-hFc) and WUCAM/Baf3 cells (PMID: 19197944). The biotinylated antibody can be used for the detection of soluble PVR-hFc in an ELISA (PMID: 20201043). The upregulation of PVR (CD155) in Jurkat cells, when transduced with WPI or HIV-1 NL4-3 strain (VprWT) lentivirus was studied using flow cytometry (PMID: 24045107). This antibody was used for identification of surface expression of DNAM1 ligands on MM cell lines by immunofluorescence staining. This antibody was also used of the immunoprecipitation of CD155 from ARK cell lysates (PMID: 28874810).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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