Vector Labs Ab03741-23.0 Anti-IL23 (p19) [G23-8], Rabbit IgG, kappa (100 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: G23-8
Synonyms: IL23A; IL-23p19; IL23p19; IL23-p19; IL-23p19; SGRF; Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19
Amount: 100 μg
Application Codes Clone: neutralize; ELISA; functional assay
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2b
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds p19 subunit of mouse interleukin-23 (IL-23). IL-23A associates with IL-12B to form IL-23 interleukin which is a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokine IL-17. Mouse IL-23 also induces strong proliferation of memory T cells. IL-23 is secreted by activated dendritic cells.
Application Notes: This antibody can neutralize the bioactivity of IL-23 with no effect on IL-12 p70 bioactivity. This antibody can be used for the detection of mouse IL-23 p19 in an ELISA (PMID: 18802055). This antibody was used in assay to determine the effect of anti-IL23p19 antibody on increase in IL-17 production after neutralization of IL-4 in T cells cultured with IL-4 DCs or with non transduced DCs (PMID: 17195211). This antibody was reported to inhibit lactic acid-induced enhancement of IL-17 production by OT-II mouse splenocytes that had been stimulated with the TLR ligand peptidoglycan (PGN) and bacillus Calmette-Gue´rin cell wall skeleton (BCG-CWS) (PMID: 18490716).

Product Class:	Purified
Clone ID:	G23-8
Synonyms:	IL23A; IL-23p19; IL23p19; IL23-p19; IL-23p19; SGRF; Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19
Amount:	100 μg
Application Codes Clone:	neutralize; ELISA; functional assay
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2b
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds p19 subunit of mouse interleukin-23 (IL-23). IL-23A associates with IL-12B to form IL-23 interleukin which is a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokine IL-17. Mouse IL-23 also induces strong proliferation of memory T cells. IL-23 is secreted by activated dendritic cells.
Application Notes:	This antibody can neutralize the bioactivity of IL-23 with no effect on IL-12 p70 bioactivity. This antibody can be used for the detection of mouse IL-23 p19 in an ELISA (PMID: 18802055). This antibody was used in assay to determine the effect of anti-IL23p19 antibody on increase in IL-17 production after neutralization of IL-4 in T cells cultured with IL-4 DCs or with non transduced DCs (PMID: 17195211). This antibody was reported to inhibit lactic acid-induced enhancement of IL-17 production by OT-II mouse splenocytes that had been stimulated with the TLR ligand peptidoglycan (PGN) and bacillus Calmette-Gue´rin cell wall skeleton (BCG-CWS) (PMID: 18490716).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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