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Mfg Part Number

Ab03745-23.0

Vector Labs Ab03745-23.0 Anti-CD112 [Nec1-803-2], Rabbit IgG, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated be immunizing KM mice with an emulsion prepared by mixing the Nectin-2ED-Fc protein and Nectin-2ED-FLAG protein.

$570.70

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Description

Product Class: Purified
Clone ID: Nec1-803-2
Synonyms: Nectin-2; NECTIN2; HVEB; PRR2; PVRL2; Herpes virus entry mediator B; Herpesvirus entry mediator B; Nectin cell adhesion molecule 2; Poliovirus receptor-related protein 2
Amount: 100 μg
Application Codes Clone: functional assay; inhibit; ELISA; FC
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds an epitope between amino acids 47-142 of the human CD112 (Nectin-2) and does not cross reacts with cynomolgus monkey CD112. It is also capable of binding G113R and H128R mutants of human CD112. Nectin-2 acts as a modulator of T-cell signaling. It can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation.
Application Notes: The binding of this antibody to CD112 or Nectin-2 expressed on the surface of CHO cells was determined using whole cell ELISA. The reactivity of this antibody for human CD112 expressed on CHO-K1 cells was checked using flow cytometry. This antibody shows good ADCC activity against OV-90 human ovarian cancer cell lines. The in-vivo anti-tumor activity of this antibody was checked in nude mice models subcutaneously-transplanted with the OV-90 human ovarian cancer cell line (US20100008928).

Product Class:	Purified
Clone ID:	Nec1-803-2
Synonyms:	Nectin-2; NECTIN2; HVEB; PRR2; PVRL2; Herpes virus entry mediator B; Herpesvirus entry mediator B; Nectin cell adhesion molecule 2; Poliovirus receptor-related protein 2
Amount:	100 μg
Application Codes Clone:	functional assay; inhibit; ELISA; FC
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds an epitope between amino acids 47-142 of the human CD112 (Nectin-2) and does not cross reacts with cynomolgus monkey CD112. It is also capable of binding G113R and H128R mutants of human CD112. Nectin-2 acts as a modulator of T-cell signaling. It can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation.
Application Notes:	The binding of this antibody to CD112 or Nectin-2 expressed on the surface of CHO cells was determined using whole cell ELISA. The reactivity of this antibody for human CD112 expressed on CHO-K1 cells was checked using flow cytometry. This antibody shows good ADCC activity against OV-90 human ovarian cancer cell lines. The in-vivo anti-tumor activity of this antibody was checked in nude mice models subcutaneously-transplanted with the OV-90 human ovarian cancer cell line (US20100008928).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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