Mfg Part Number
Ab03747-3.0
Vector Labs Ab03747-3.0 Anti-Claudin-18.2 [CLDN18.2-v.19], Mouse IgG2b, kappa (100 μg)
Quick Overview
The original antibody was generated by grafting CDRs of the parental mouse antibody onto human framework regions.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | CLDN18.2-v.19 |
| Synonyms: | CLDN18.2; 2C6.9-HZ21; HuCLDN18.2-v. 19; CLDN18.2 v. 19 |
| Amount: | 100 μg |
| Application Codes Clone: | FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for human claudin-18.2 with no cross reactivity with claudin 18.1. Alterations in claudin expression can impair tight junction function, influence signaling pathways, and act as a tumor-promoting event in some epithelial cancers. Claudin 18.2 is overexpressed in various tumor type and is found to be a potentially important target in advanced gastric cancer. |
| Application Notes: | The binding specificity of this antibody to human Claudin 18.2 expressed on the surface of HEK293 cells and Kato III cells was done using flow cytometry. The in-vivo anti-tumor activity of this antibody was evaluated in a syngeneic Mc38-huCLDN18.2 xenograft model in mice, which is a murine claudin18.2-/-mouse colon cancer cell line that has been engineered to expresses human claudin 18.2 (WO2021047599). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |