Vector Labs Ab03748-10.3 Anti-CART [AH36], Human IgG1, Fc Silent™, kappa (100 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: AH36
Heavy Chain Modification: Fc Silent™
Synonyms: CARTPT; Cocaine-amphetamine regulated transcript peptide; neurotransmitter
Amount: 100 μg
Application Codes Clone: ELISA; in vivo
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: scFv
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This full-length, chimeric human antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody specifically binds cocaine-amphetamine regulated transcript peptide also known as CART, which is a widely distributed neurotransmitter expressed in the central nervous systems. Studies have shown the role of CART in food intake, maintenance of bodyweight, stress control, reward and pain transmission. Repeated administration of psychostimulants enhances expression of CART peptide. Nucleus accumbal-injected CART peptide plays a positive role in the regulation of behavioral sensitization induced by psychostimulants and regulated the mesocorticolimbic dopaminergic pathway. CART peptide also exerted an inhibitory effect on psychostimulant-enhanced dopamine receptors signaling, Ca2+/calmodulin-dependent kinase signaling and crucial transcription factors expression.
Application Notes: The binding reactivity of this antibody to CART was checked using ELISA. The in-vivo administration of this antibody in mice had no effects on the normal spontaneous activities of the animal. However, when mice were given this antibody intraperitoneally before administration of cocaine, it inhibited the expression of cocaine-induced animal behavioral sensitization (CN101280016). This antibody is recommended for studies relating to treatment of drug addiction.

Product Class:	Purified
Clone ID:	AH36
Heavy Chain Modification:	Fc Silent™
Synonyms:	CARTPT; Cocaine-amphetamine regulated transcript peptide; neurotransmitter
Amount:	100 μg
Application Codes Clone:	ELISA; in vivo
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	scFv
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This full-length, chimeric human antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody specifically binds cocaine-amphetamine regulated transcript peptide also known as CART, which is a widely distributed neurotransmitter expressed in the central nervous systems. Studies have shown the role of CART in food intake, maintenance of bodyweight, stress control, reward and pain transmission. Repeated administration of psychostimulants enhances expression of CART peptide. Nucleus accumbal-injected CART peptide plays a positive role in the regulation of behavioral sensitization induced by psychostimulants and regulated the mesocorticolimbic dopaminergic pathway. CART peptide also exerted an inhibitory effect on psychostimulant-enhanced dopamine receptors signaling, Ca2+/calmodulin-dependent kinase signaling and crucial transcription factors expression.
Application Notes:	The binding reactivity of this antibody to CART was checked using ELISA. The in-vivo administration of this antibody in mice had no effects on the normal spontaneous activities of the animal. However, when mice were given this antibody intraperitoneally before administration of cocaine, it inhibited the expression of cocaine-induced animal behavioral sensitization (CN101280016). This antibody is recommended for studies relating to treatment of drug addiction.

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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