Mfg Part Number
Ab03749-23.0
Vector Labs Ab03749-23.0 Anti-Cocaine [15A10], Rabbit IgG, lambda (100 μg)
Quick Overview
The original antibody was generated by immunizing BALB/c mice with BSA conjugated transition state analogs of cocaine.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | 15A10 |
| Synonyms: | Benzoylmethylecgonine; coca; coke; crack; ChEBI: 27958 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; in vivo |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody hydrolyzes the benzoyl ester of cocaine to form the nonpsychoactive metabolites benzoic acid and ecgonine methylester. Cocaine is a strong stimulant used clinically as a local analgesic and vasoconstrictor and illegally as a recreational drug. |
| Application Notes: | This catalytic antibody is capable of cocaine to its non psychoactive metabolites. The rate of acceleration of the catalytic antibody was reported to be (kcat/kuncat = 2.3 × 10^4). Competitive ELISA was used for the detection of binding of this antibody to the transition-state analogue of cocaine (Yang et al., 1996). In a model of cocaine overdose, this antibody protected rats from cocaine-induced seizures and sudden death in a dose-dependent fashion; a noncatalytic anticocaine antibody did not reduce toxicity. In a model of cocaine addiction, this antibody blocked completely the reinforcing effect of cocaine in rats (PMID: 9707620). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |