Mfg Part Number
Ab03754-2.3
Vector Labs Ab03754-2.3 Anti-Morphine [M86], Mouse IgG2a, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing BALB/c mice with morphine-BSA conjugated fusion protein. A mouse scFv library was generated from the spleen cells and the particular antibody was isolated by panning against morphine-conjugated thyroglobulin (morphine-C-Tg).
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| Product Class: | Purified |
|---|---|
| Clone ID: | M86 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Morphium; Codeine; Heroin; Opium; ChEBI: 17303; FERM ABP-11378 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This full-length, reformatted mouse antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds morphine and cross reacts with other opioids like opium, codeine and heroin. Morphine is a strong opiate that is found naturally in opium, a dark brown resin in poppies (Papaver somniferum). It is considered the classic opioid analgesic, most commonly used in pain management, morphine provides major relief to patients afflicted with pain. It is a non-synthetic narcotic with a high potential for abuse. |
| Application Notes: | The binding reactivity of this antibody for morphine conjugated thyroglobulin (morphine-C-Tg) was done using ELISA. The original scFv antibody binds morphine-C-Tg with a binding affinity of Kd= 0.126 nM. It was reported that this antibody does not cross react with thyroglobulin conjugated codeine-, cocaine-, or ketamine. However, this antibody is capable of cross reacting with free morphine, opium, codeine and heroin. The IC50 values of M86 scFv for opium, morphine, codeine and heroin was 257 ng/mL, 36.4, 7.3 and 7.4 nM, respectively (Matsukizono et al., 2013; JP2012232948). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |