Mfg Part Number
Ab03787-23.0
Vector Labs Ab03787-23.0 Anti-SAR-55 ORF2 [HEV#31], Rabbit IgG, kappa (100 μg)
Quick Overview
A chimpanzee previously infected with specific viral pathogens was used as a source of bone marrow lymphocytes for the construction of a phage display library. The original antibody was isolated from this library.
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| Product Class: | Purified |
|---|---|
| Clone ID: | HEV#31 |
| Synonyms: | HEV; Secreted protein ORF2; Protein ORF2; pORF2 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; WB; Neutralization; SPR; RIA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | Fab |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This is a reformatted, chimeric antibody made using the variable domain sequences of the original human Fab antibody to improve compatibility with existing reagents, assays, and techniques. |
| Specificity Statement: | The antibody is specific for HEV. The antibody recognizes an epitope on the SAR-55 ORF2 protein. The antibody also recognises swine HEV. |
| Application Notes: | The specificity of the original format of the antibody for SAR-55 ORF2 protein and swine HEV was confirmed by ELISA analysis (Kd= 0.8 and 1.3 nM respectively). The antibody recognized reduced, denatured HEV ORF2 protein by Western Blot. The antibody strongly precipitated the construct corresponding to aa112–607 of the ORF2 protein by radioimmunoprecipitation. The binding affinity of the antibody to SAR-55 ORF2 protein was measured by surface plasmon resonance (Kd= 4.5 nM). The original antibody was able to neutralize the SAR-55 strain of HEV, as determined by intravenous challenge of rhesus monkeys (US7148323B2). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |