JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

Skip to the beginning of the images gallery

Mfg Part Number

Ab03794-10.3

Vector Labs Ab03794-10.3 Anti-CD44v6 [BIWA8], Human IgG1, Fc Silent™, kappa (100 μg)

VECTOR LABS

Be the first to review this product

Quick Overview

The antibody is the humanized version of the murine BIWA-1.

$570.70

Order will ship within 1-3 business days

Description

Product Class: Purified
Clone ID: BIWA8
Heavy Chain Modification: Fc Silent™
Synonyms: CD44 antigen; CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I
Amount: 100 μg
Application Codes Clone: in vivo
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: The antibody is specific for CD44v6. CD44v6 is a tumor associated antigen abundantly expressed in head and neck squamous cell carcinomas (HNSCC) and in normal squamous epithelium.
Application Notes: The antibody is the mutated version of BIWA-4 that was constructed with the aim of improving binding affinity. The binding affinity of the antibody to CD44v6 was measured by surface plasmon resonance. The antibody showed a specificity of tumor localization when administrated together with another anti-CD44v6 antibody to mice in in vivo experiments (Verel et al. 2002; PMID: 11992408). The specificity of the humanized version of the antibody was confirmed by ELISA anlaysis (Kd= 0.84 nM). The antibody had good therapeutic efficacy in in vivo experiments in mice. Mice treated with labelled 186Re-BIWA 8 showed a decreased in the tumor volume (US6972324B2).

Product Class:	Purified
Clone ID:	BIWA8
Heavy Chain Modification:	Fc Silent™
Synonyms:	CD44 antigen; CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I
Amount:	100 μg
Application Codes Clone:	in vivo
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	The antibody is specific for CD44v6. CD44v6 is a tumor associated antigen abundantly expressed in head and neck squamous cell carcinomas (HNSCC) and in normal squamous epithelium.
Application Notes:	The antibody is the mutated version of BIWA-4 that was constructed with the aim of improving binding affinity. The binding affinity of the antibody to CD44v6 was measured by surface plasmon resonance. The antibody showed a specificity of tumor localization when administrated together with another anti-CD44v6 antibody to mice in in vivo experiments (Verel et al. 2002; PMID: 11992408). The specificity of the humanized version of the antibody was confirmed by ELISA anlaysis (Kd= 0.84 nM). The antibody had good therapeutic efficacy in in vivo experiments in mice. Mice treated with labelled 186Re-BIWA 8 showed a decreased in the tumor volume (US6972324B2).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

Reviews