Mfg Part Number
Ab03804-10.3
Vector Labs Ab03804-10.3 Anti-PD-1 [Anti-human PD-1 antibody], Human IgG1, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing transgenic mice with PD-1.
$570.70
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | Anti-human PD-1 antibody |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | CD279; Programmed cell death protein 1; PDCD1; PD-1; hPD-1; Human programmed cell death receptor-1 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; Blocking; Inhibition |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody is specific for PD-1. The antibody binds the extracellular region of the human PD-1 protein receptor. PD-1 is a type I membrane protein with 288 amino acids, and is one of the main known immune checkpoints. PD-1 is expressed in activated T lymphocytes, and it binds ligands PD-L1 and PD-L2. |
| Application Notes: | The specificity of the original format of the antibody was confirmed by ELISA analysis (EC50 = 76 pM). The antibody blocked the binding between PD-1 protein and its ligands PD-L1 and PD-L2 by the receptor ligand binding assay of PD-1 protein. Lymphocyte stimulation assay detected that PD-1 antibody blocked the binding of PD-1 protein to its ligands PD-L1 and PD-L2, thereby releasing its inhibition of T lymphocyte activity (CN106928361A). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |