Mfg Part Number
Ab03806-10.0
Vector Labs Ab03806-10.0 Anti-C3 [C3-2], Human IgG1, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing mice with purified human C3.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | C3-2 |
| Synonyms: | Anti-C3-2 mAb; third component of complement; Complement C3; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; WB; Inhibition; SPR |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody interacts specifically with native C3, containing an intact thioester bond and not with an inactive form of C3, containing a hydrolysed ester bond. The epitope in part located on the 23kD-α-chain fragment of C3c. |
| Application Notes: | The specificity of the original format of the antibody was confirmed by ELISA analysis. The binding affinity of the humanised version of the antibody to native C3 was measured by surface plasmon resonance (Kd= 5.9 nM). The murine and the humanised version of the antibody could inhibit the activation of C3 (WO2004031240A1). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |