Mfg Part Number
Ab03812-10.3
Vector Labs Ab03812-10.3 Anti-cytochrome C [R1D3], Human IgG1, Fc Silent™, kappa (100 μg)
Quick Overview
Vector Labs Ab03812-10.3 Anti-cytochrome C [R1D3], Human IgG1, Fc Silent™, kappa (100 μg)
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | R1D3 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | cyt c; Cytochrome c somatic |
| Amount: | 100 μg |
| Application Codes Clone: | ICC |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 36378644 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody is specific for cytochrome c. The antibody binds to a variety of oxidatively modified cyt c species, such as nitrated at Tyr74 or oxidized at Met80, which lose the sixth heme ligation (Fe-Met80); it does not bind to several cyt c phospho- and acetyl-mimetics. |
| Application Notes: | The antibody was employed to identify alternative conformations of cyt c in cells under oxidant- or senescence-induced challenge as confirmed by immunocytochemistry (Tomasina et al., 2022; PMID: 36378644). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |