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Mfg Part Number

Ab03830-10.3

Vector Labs Ab03830-10.3 Anti-MUC1-C/ECD [6A6], Human IgG1, Fc Silent™, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing C57Bl/6 mice with a protein containing ECD of MUC1-C fused to the Fc portion of mouse immunoglobulin (MUC1-C/ECD-mFc).

$570.70

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Description

Product Class: Purified
Clone ID: 6A6
Heavy Chain Modification: Fc Silent™
Synonyms: MUC1-C/extracellular domain; Mucin-1; MUC-1; Breast carcinoma-associated antigen DF3; Cancer antigen 15-3 (CA 15-3); Carcinoma-associated mucin; Episialin; H23AG; Krebs von den Lungen-6 (KL-6); PEMT; Peanut-reactive urinary mucin (PUM); Polymorphic epithelial mucin (PEM); Tumor-associated epithelial membrane antigen (EMA); Tumor-associated mucin
Amount: 100 μg
Application Codes Clone: FC; ELISA; WB; therapeutic
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: The antibody is specific for MUC1-C/ECD.
Application Notes: The specificity of the original format of the antibody was confirmed by ELISA analysis. This antibody was used for detection of MUC1-C/ECD expressed on ZR-75-1 breast carcinoma or H-1975 NSCLC cell lines by flow cytometry. The antibody detected the recombinant chIL-2 by western blot analysis (US10059775B2). The scFv version of this antibody was successfully used to deliver gemcitabine to MUC1-positive pancreatic cancer cells, enhancing chemosensitivity and inducing immunogenic cell death in both in vitro and in vivo models of pancreatic ductal adenocarcinoma (PDAC) (Guo et al., 2024; DOI: 10.1002/smm2.1279).

Product Class:	Purified
Clone ID:	6A6
Heavy Chain Modification:	Fc Silent™
Synonyms:	MUC1-C/extracellular domain; Mucin-1; MUC-1; Breast carcinoma-associated antigen DF3; Cancer antigen 15-3 (CA 15-3); Carcinoma-associated mucin; Episialin; H23AG; Krebs von den Lungen-6 (KL-6); PEMT; Peanut-reactive urinary mucin (PUM); Polymorphic epithelial mucin (PEM); Tumor-associated epithelial membrane antigen (EMA); Tumor-associated mucin
Amount:	100 μg
Application Codes Clone:	FC; ELISA; WB; therapeutic
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	The antibody is specific for MUC1-C/ECD.
Application Notes:	The specificity of the original format of the antibody was confirmed by ELISA analysis. This antibody was used for detection of MUC1-C/ECD expressed on ZR-75-1 breast carcinoma or H-1975 NSCLC cell lines by flow cytometry. The antibody detected the recombinant chIL-2 by western blot analysis (US10059775B2). The scFv version of this antibody was successfully used to deliver gemcitabine to MUC1-positive pancreatic cancer cells, enhancing chemosensitivity and inducing immunogenic cell death in both in vitro and in vivo models of pancreatic ductal adenocarcinoma (PDAC) (Guo et al., 2024; DOI: 10.1002/smm2.1279).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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