Mfg Part Number
Ab03834-10.3
Vector Labs Ab03834-10.3 Anti-CD98 [18-2a 7.1], Human IgG1, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing male 129S6/SvEv mice with human CD98 (huCD98)-expressing tumor cells.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | 18-2a 7.1 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | LAT1; E16; MPE16; SLC7A5 |
| Amount: | 100 μg |
| Application Codes Clone: | FACS; SPR |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody is specific for CD98. |
| Application Notes: | Binding affinities of the murine and chimeric version of the antibody were determined using FACS analysis (Kd values between 0.9 nM and 4.5 nM). The chimeric antibody was also subjected to FACS analysis using three AML primary tumor samples and one cell line expressing cynomolgus monkey CD98 (cynCD98). The results demonstrated that the chimeric retained binding to human CD98 on AML cells and on cynCD98. The binding affinity of the murine, chimeric and humanized version of the antibody to CD98 was measured by surface plasmon resonance (JP2015501639A5). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |