Mfg Part Number
Ab03840-5.0
Vector Labs Ab03840-5.0 Anti-Rotavirus A capsid glycoprotein VP7 [4F8], Mouse IgG3, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing mice with partially purified RRV.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | 4F8 |
| Synonyms: | VP7; RRV VP7; RRV capsid protein; outer capsid glycoprotein; capsid protein; rhesus rotavirus; RRV |
| Amount: | 100 μg |
| Application Codes Clone: | Neutralize; ELISA; Crystallization |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG3 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds the outer capsid glycoprotein VP7 of the Rotavirus A serotype 3. This antibody can bind rhesus and equine strains of Rotaviruses. Rotavirus is a genus of double-stranded RNA viruses in the family Reoviridae. A rotavirus infection is a contagious disease in which inflammation of the stomach and intestines occurs causing severe, watery diarrhea and vomiting in infants and young children. Nearly every child develops a rotavirus infection before the age of five. |
| Application Notes: | This antibody neutralized serotype 3 rotaviruses RRV and simian rotavirus (SA11) in plaque reduction neutralization assay and protected suckling mice in vivo against serotype 3 (RRV and SA11) but not against OSU or UK virus challenge (Offit et al., 1986; PMID: 2422398). This antibody was used to detect rotaviruses from stools of infants with gastroenteritis using ELISA (Padilla-Noriega et al., 1990; PMID: 2166073). The crystal structure of the Fab fragment of the antibody in complex with rhesus rotavirus (RRV, serotype G3) VP7 trimer was determined. The Fab fragment showed a stronger neutralization activity against RRV than the original format (Aoki et al., 2009; PMID: 19520960). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |