Mfg Part Number
Ab03863-1.1
Vector Labs Ab03863-1.1 Anti-ROR1 [M508], Mouse IgG1, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing wild-type mice with full-length extracellular portion of human ROR1 protein.
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| Product Class: | Purified |
|---|---|
| Clone ID: | M508 |
| Synonyms: | NTRKR1; Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase, receptor-related 1; R12 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; FC; functional assay |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds the human ROR1. ROR1 is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. It is a pseudo kinase that lacks catalytic activity. Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is overexpressed in many types of malignant tumors. Antibody-based immunotherapies targeting ROR1 have been developed and evaluated in preclinical and clinical studies with promising outcomes. |
| Application Notes: | The binding reactivity of this antibody to full-length extracellular portion of human ROR1 protein and its truncated forms was done using ELISA. The binding reactivity and specificity of this antibody was comparable with another anti-ROR1 antibody R12. The mouse-human chimeric IgG1 version of this antibody binds human ROR1 with a binding affinity of Kd= 1.4 nM. This antibody could bind human ROR1 expressed on the surface of breast cancer cell line MDA-MB-231 in a flow cytometric assay. This antibody is recommended for detection of human ROR1 expressing tumor cells (CN114539411). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |