Mfg Part Number
Ab03874-23.0
Vector Labs Ab03874-23.0 Anti-CD277 [108.5], Rabbit IgG, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing BALB/c mice with soluble BT3.1-Ig fusion protein.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | 108.5 |
| Synonyms: | BTN3A1; BTF5; BT3; BT3.1; Butyrophilin subfamily 3 member A1 |
| Amount: | 100 μg |
| Application Codes Clone: | antagonist; functional assay |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds human CD277 (BTNA3A1). This protein plays an important role in T-cell activation and in the adaptive immune response. It regulates proliferation of activated T-cells and release of IFNG by activated T-cells. It is expressed on surface of T-cells, natural killer cells, dendritic cells and macrophages (at protein level). It is highly expressed in heart, pancreas and lung and moderately expressed in placenta, liver and muscle. |
| Application Notes: | This antibody was used as an antagonist antibody to check if BTN3A can specifically enhance Vg9Vd2 TCR-mediated lysis of primary AML blasts using cytotoxic assays. This antibody was reported to significantly and drastically abrogate zoledronate (ZOL)-induced lysis (PMID: 27853633). This antibody can completely abrogate Vγ9Vδ2 T cell mediated lysis of tumors (PMID: 29296524). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |