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Mfg Part Number

Ab03880-23.0

Vector Labs Ab03880-23.0 Anti-CD70 [3H4], Rabbit IgG, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing BALB/c mice with recombinant human CD70-mFc fusion protein as immunogen.

$570.70

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Description

Product Class: Purified
Clone ID: 3H4
Synonyms: TNFSF7; CD27L; CD27-L; CD27LG; CD27 ligand; CD70 antigen; Tumor necrosis factor ligand superfamily member 7
Amount: 100 μg
Application Codes Clone: FC; ELISA
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds human and cynomolgus monkey CD70, a cytokine belonging to the tumor necrosis factor (TNF) ligand family, which acts as a ligand for TNFRSF27/CD27. It is a surface antigen present on activated T and B cells. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. CD70 is also identified as an emerging target in cancer immunotherapy.
Application Notes: The binding this antibody to recombinant human CD70 was determined using ELISA. This antibody can positively react with human and cynomolgus monkey CD70 expressed on the surface of 786-0 renal carcinoma cells and CHO-K1-cmCD70 cells in a flow cytometric assay (CN110724670).

Product Class:	Purified
Clone ID:	3H4
Synonyms:	TNFSF7; CD27L; CD27-L; CD27LG; CD27 ligand; CD70 antigen; Tumor necrosis factor ligand superfamily member 7
Amount:	100 μg
Application Codes Clone:	FC; ELISA
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds human and cynomolgus monkey CD70, a cytokine belonging to the tumor necrosis factor (TNF) ligand family, which acts as a ligand for TNFRSF27/CD27. It is a surface antigen present on activated T and B cells. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. CD70 is also identified as an emerging target in cancer immunotherapy.
Application Notes:	The binding this antibody to recombinant human CD70 was determined using ELISA. This antibody can positively react with human and cynomolgus monkey CD70 expressed on the surface of 786-0 renal carcinoma cells and CHO-K1-cmCD70 cells in a flow cytometric assay (CN110724670).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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