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Mfg Part Number

Ab03881-3.3

Vector Labs Ab03881-3.3 Anti-SIRP alpha [12G6], Mouse IgG2b, Fc Silent™, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing BALB/c mice with recombinant human SIRPα-hFc fusion protein.

$570.70

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Description

Product Class: Purified
Clone ID: 12G6
Heavy Chain Modification: Fc Silent™
Synonyms: CD172a; SIRPα; SIRPA; Signal regulatory protein α; Signal regulatory protein alpha; Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3; p84
Amount: 100 μg
Application Codes Clone: FC; ELISA; block
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2b
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement: This antibody binds human and cynomolgus monkey SIRP alpha, which is a regulatory membrane glycoprotein and an immunoglobulin-like cell surface receptor for CD47. This protein plays a key role in intracellular signaling during synaptogenesis and in synaptic function. Cancer cells highly express CD47 that activates SIRPα and inhibit macrophage-mediated destruction.
Application Notes: The binding reactivity of this antibody towards recombinant human SIRPα-his fusion protein was checked using ELISA. Flow cytometry was used to detect the binding of the antibody to SIRPα on the membrane of human and cynomolgus monkey SIRPα overexpressed cells. This antibody binds cynomolgus monkey SIRPα with a weaker binding affinity than human SIRPα. This antibody can effectively block the binding of CD47 protein to cell surface SIRPα (CN110734897).

Product Class:	Purified
Clone ID:	12G6
Heavy Chain Modification:	Fc Silent™
Synonyms:	CD172a; SIRPα; SIRPA; Signal regulatory protein α; Signal regulatory protein alpha; Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3; p84
Amount:	100 μg
Application Codes Clone:	FC; ELISA; block
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2b
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement:	This antibody binds human and cynomolgus monkey SIRP alpha, which is a regulatory membrane glycoprotein and an immunoglobulin-like cell surface receptor for CD47. This protein plays a key role in intracellular signaling during synaptogenesis and in synaptic function. Cancer cells highly express CD47 that activates SIRPα and inhibit macrophage-mediated destruction.
Application Notes:	The binding reactivity of this antibody towards recombinant human SIRPα-his fusion protein was checked using ELISA. Flow cytometry was used to detect the binding of the antibody to SIRPα on the membrane of human and cynomolgus monkey SIRPα overexpressed cells. This antibody binds cynomolgus monkey SIRPα with a weaker binding affinity than human SIRPα. This antibody can effectively block the binding of CD47 protein to cell surface SIRPα (CN110734897).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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