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Mfg Part Number

Ab03888-10.0

Vector Labs Ab03888-10.0 Anti-HBV pre-S1 protein [MA18/7], Human IgG1, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing mice with HBsAg subtype ayw.

$570.70

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Description

Product Class: Purified
Clone ID: MA18/7
Synonyms: PreS1; Large envelope protein; L glycoprotein; L-HBsAg; Large S protein; Large surface protein; Major surface antigen
Amount: 100 μg
Application Codes Clone: inhibit; neutralize; ELISA; WB; functional assay
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds a clearly defined epitope 'DPAF' (amino acids 31-34) of the pre-S1 region of the hepatitis B virus. Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). It can cause chronic infection and puts people at high risk of death from cirrhosis and liver cancer.
Application Notes: This antibody can be used for the identification of HBV pre-S2 protein using immunoblot and western blot (PMID: 6492255). The original mouse IgG1 version of this antibody was reported to bind pre-S1 protein of HBV with a binding affinity of Kd= 0.24 nM (PMID: 10509818). Immunoblot analysis revealed that the tetrapeptide Asp-Pro-Ala-Phe (DPAF), located at the position preS(31–34) and conserved in all known HBV genomes, is sufficient to bind MA18/7 antibody (PMID: 1279369). It was reported that MA18/7 inhibits the binding of natural HBV to hepatocyte membranes (PMID: 7964611). This antibody has shown to neutralize infectivity of HBV for primary human hepatocytes, also blocked infection of primary Tupaia belangeri hepatocytes (PMID: 12915565).

Product Class:	Purified
Clone ID:	MA18/7
Synonyms:	PreS1; Large envelope protein; L glycoprotein; L-HBsAg; Large S protein; Large surface protein; Major surface antigen
Amount:	100 μg
Application Codes Clone:	inhibit; neutralize; ELISA; WB; functional assay
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds a clearly defined epitope 'DPAF' (amino acids 31-34) of the pre-S1 region of the hepatitis B virus. Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). It can cause chronic infection and puts people at high risk of death from cirrhosis and liver cancer.
Application Notes:	This antibody can be used for the identification of HBV pre-S2 protein using immunoblot and western blot (PMID: 6492255). The original mouse IgG1 version of this antibody was reported to bind pre-S1 protein of HBV with a binding affinity of Kd= 0.24 nM (PMID: 10509818). Immunoblot analysis revealed that the tetrapeptide Asp-Pro-Ala-Phe (DPAF), located at the position preS(31–34) and conserved in all known HBV genomes, is sufficient to bind MA18/7 antibody (PMID: 1279369). It was reported that MA18/7 inhibits the binding of natural HBV to hepatocyte membranes (PMID: 7964611). This antibody has shown to neutralize infectivity of HBV for primary human hepatocytes, also blocked infection of primary Tupaia belangeri hepatocytes (PMID: 12915565).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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