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Mfg Part Number

Ab03901-10.3

Vector Labs Ab03901-10.3 Anti-CD155 [CD155.16 ], Human IgG1, Fc Silent™, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing KAC mice (KAC mouse is a genetically engineered mouse strain that expresses BAP -Biotin Accepting Peptide, sequence on constant part of kappa chain) subcutaneously with CD155-Fc fusion protein.

$570.70

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Description

Product Class: Purified
Clone ID: CD155.16
Heavy Chain Modification: Fc Silent™
Synonyms: PVR; PVS; NECL-5; Poliovirus receptor; Nectin-like protein 5
Amount: 100 μg
Application Codes Clone: FC
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds human CD155 also called the poliovirus receptor (PVR). The binding of this antibody does not block binding of TIGIT to CD155/PVR. This protein mediates NK cell adhesion and triggers NK cell function. It also binds two NK cell receptors CD96 and CD226. CD155 is gaining more interest as a therapeutic target in the field of tumor immunology due to its prominent endogenous and immune functions.
Application Notes: This antibody was used to identify CD155 expression on U-87 MG and U-87 MG PVRhi cell lines using flow cytometry. This antibody was used in the generation of anti-CD155 -saporin and anti-CD155-diphtheria immunotoxins and were tested for its antitumor activity. Cytotoxic effect was determined by ToxiLight kit. The results suggested that the immunotoxins were successful in killing CD155 expressing tumor cells.(WO2019102456).

Product Class:	Purified
Clone ID:	CD155.16
Heavy Chain Modification:	Fc Silent™
Synonyms:	PVR; PVS; NECL-5; Poliovirus receptor; Nectin-like protein 5
Amount:	100 μg
Application Codes Clone:	FC
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds human CD155 also called the poliovirus receptor (PVR). The binding of this antibody does not block binding of TIGIT to CD155/PVR. This protein mediates NK cell adhesion and triggers NK cell function. It also binds two NK cell receptors CD96 and CD226. CD155 is gaining more interest as a therapeutic target in the field of tumor immunology due to its prominent endogenous and immune functions.
Application Notes:	This antibody was used to identify CD155 expression on U-87 MG and U-87 MG PVRhi cell lines using flow cytometry. This antibody was used in the generation of anti-CD155 -saporin and anti-CD155-diphtheria immunotoxins and were tested for its antitumor activity. Cytotoxic effect was determined by ToxiLight kit. The results suggested that the immunotoxins were successful in killing CD155 expressing tumor cells.(WO2019102456).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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