Mfg Part Number
Ab03903-10.0
Vector Labs Ab03903-10.0 Anti-CD155 [scFv3], Human IgG1, kappa (100 μg)
Quick Overview
The original antibody was isolated from an scFv phage display library generated by immunizing two BALB/c mice intradermally with paraformaldehyde fixed HT1080 cells (human fibrosarcoma cell line).
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| Product Class: | Purified |
|---|---|
| Clone ID: | scFv3 |
| Synonyms: | PVR; PVS; NECL-5; Poliovirus receptor; Nectin-like protein 5 |
| Amount: | 100 μg |
| Application Codes Clone: | functional assay |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This full-length, chimeric human antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds human CD155 also called the poliovirus receptor (PVR). This protein mediates NK cell adhesion and triggers NK cell function. It also binds two NK cell receptors CD96 and CD226. CD155 is gaining more interest as a therapeutic target in the field of tumor immunology due to its prominent endogenous and immune functions. |
| Application Notes: | This antibody show inhibitory effect on the invasion of HT1080 cells, MDA-MD231 cells in a chemotaxis assay with a Matrigel coated cell migration chamber. This antibody also has inhibitory effect on the migration of two different glioblastoma cell lines U87MG and A172 (US20090215175). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |