Mfg Part Number
Ab03908-23.0
Vector Labs Ab03908-23.0 Anti-Claudin-18.2 [2C6.9], Rabbit IgG, kappa (100 μg)
Quick Overview
Vector Labs Ab03908-23.0 Anti-Claudin-18.2 [2C6.9], Rabbit IgG, kappa (100 μg)
$570.70
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | 2C6.9 |
| Synonyms: | CLDN18.2; C18-23-3G-1E1 |
| Amount: | 100 μg |
| Application Codes Clone: | functional assay |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for human claudin-18.2. Alterations in claudin expression can impair tight junction function, influence signaling pathways, and act as a tumor-promoting event in some epithelial cancers. Claudin 18.2 is overexpressed in various tumor type and is found to be a potentially important target in advanced gastric cancer. |
| Application Notes: | This antibody can be used for the detection of human claudin 18.2. This antibody was also used in the generation of a CAR-T cell receptor. CLDN18.2 CAR-T specifically binds to tumor cells, activated 2C6.9-T-PD-1 CAR-T alleviates or eliminates immunosuppression by secreting anti-PD-1 antibodies, increasing the anti-tumor effect. 2C6.9-T can activate primary T cells and efficiently mediate the killing of tumor cells expressing CLDN18.2 by T cells and caused a significant increase in cytokine secretion (CN113754780). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |