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Mfg Part Number

Ab03925-10.0

Vector Labs Ab03925-10.0 Anti-CEA [806.077], Human IgG1, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing BALB/C mice with CEA. The antibody was subsequently humanized.

$570.70

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Description

Product Class: Purified
Clone ID: 806.077
Synonyms: carcinoembryonic antigen; Accession No. 96022936
Amount: 100 μg
Application Codes Clone: in vivo; IHC
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG3
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted human antibody was made using the variable domain sequences of the original Human IgG3 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: The antibody is selective for CEA, exhibiting no cross reactivity to granulocytes.
Application Notes: The antibody-CPG2 conjugate showed anti-tumour activity in an ADEPT model. The antibody was employed to screen human normal and tumour tissues using sensitive three-stage indirect immunohistology on acetone-fixed, frozen cryostat sections. Further, the reactivity of the antibody was compared against A5B7. The two antibodies showed comparable results in the following tumours: colon tumours, NSCLC tumours, gastric tumours. The anti-tumour activity of the F(ab′)2-CPG2 conjugate antibody was evaluated in combination with the prodrug N(4-[N,N-bis(2-chloroethyl)amino]-phenoxycarbonyl)-L-glutamic acid in a human colorectal tumour xenograft model. The results demonstrated that the F(ab′)2-CPG2 conjugate antibody in combination with the PGP prodrug produced tumour regressions and prolonged growth delays which were statistically significant compared with control groups. The humanized version of the parental mouse antibody was also constructed (US6903203B2).

Product Class:	Purified
Clone ID:	806.077
Synonyms:	carcinoembryonic antigen; Accession No. 96022936
Amount:	100 μg
Application Codes Clone:	in vivo; IHC
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG3
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted human antibody was made using the variable domain sequences of the original Human IgG3 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	The antibody is selective for CEA, exhibiting no cross reactivity to granulocytes.
Application Notes:	The antibody-CPG2 conjugate showed anti-tumour activity in an ADEPT model. The antibody was employed to screen human normal and tumour tissues using sensitive three-stage indirect immunohistology on acetone-fixed, frozen cryostat sections. Further, the reactivity of the antibody was compared against A5B7. The two antibodies showed comparable results in the following tumours: colon tumours, NSCLC tumours, gastric tumours. The anti-tumour activity of the F(ab′)2-CPG2 conjugate antibody was evaluated in combination with the prodrug N(4-[N,N-bis(2-chloroethyl)amino]-phenoxycarbonyl)-L-glutamic acid in a human colorectal tumour xenograft model. The results demonstrated that the F(ab′)2-CPG2 conjugate antibody in combination with the PGP prodrug produced tumour regressions and prolonged growth delays which were statistically significant compared with control groups. The humanized version of the parental mouse antibody was also constructed (US6903203B2).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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