Mfg Part Number
Ab03933-10.3
Vector Labs Ab03933-10.3 Anti-IL-34 [FAb1.1], Human IgG1, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was generated by panning a Fab library against IL-34.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | FAb1.1 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Interleukin-34; YW404.33.56 |
| Amount: | 100 μg |
| Application Codes Clone: | Blocking; Crystallization; Neutralizing |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | Fab |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted human antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody is specific for human and murine IL-34. The antibody recognizes a largely continuous area at the junction of two IL-34 protomers. The epitope overlaps largely with binding epitopes responsible for CSF-1R binding. |
| Application Notes: | The crystal structure of the Fab fragment of the antibody in complex with human IL-34 was determined. The original antibody was reformatted as an IgG molecules and the binding affinity of both formats measured by BLI experiments (Kd= 17 nM and 120 pM respectively). The antibody blocked the biological activity of IL-34 in human monocyte viability. The antibody neutralized IL-34 in a proliferation assays (Ma et al., 2012; PMID: 22483114). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |