Mfg Part Number
Ab03940-23.0
Vector Labs Ab03940-23.0 Anti-Apo E [2E8], Rabbit IgG, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing BALB/c mice with human apoE3.
$570.70
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | 2E8 |
| Synonyms: | ApoE; Apolipoprotein E |
| Amount: | 100 μg |
| Application Codes Clone: | block; ELISA |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 8558079 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds the LDL binding site 'RLASHLRKLRKRLLR' of the human apolipoprotein E. This antibody binds well with apoE3 and poorly with apoE2. Apolipoprotein E (apoE), a 299 amino acid lipoprotein, is a ligand for the low density lipoprotein receptor (LDLr). APO E is involved in the metabolism of fats and it is implicated in the Alzheimer's disease and cardiovascular diseases. It mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. |
| Application Notes: | This antibody was reported to binds to apoE and blocks apoE-mediated binding of lipoproteins to the low density lipoprotein receptor (LDLr). It was also reported that this antibody resembles LDLr in showing reduced reactivity against apoE (Arg158Cys). The reactivity of this antibody to various apoE variants was determined using ELISA (PMID: 8558079). This antibody partially blocked the binding of apoE isoforms to the immobilized VLDL receptor (PMID: 15863833). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |