Mfg Part Number
Ab03944-10.3
Vector Labs Ab03944-10.3 Anti-Ferritin [AMB8LK], Human IgG1, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing female Balb/c mice with ferritin extracted from human spleen cells.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | AMB8LK |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | FTMT; FTL; FTH1; Ferritin mitochondrial; B8 |
| Amount: | 100 μg |
| Application Codes Clone: | IP; immunotherapy; tumor imaging |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds human ferritin. This protein catalyzes the oxidation of ferrous iron(II) to ferric iron(III) and stores iron in a soluble, non-toxic, readily available form. Ferritin is important for iron homeostasis. |
| Application Notes: | This antibody was capable of immunoprecipitating ferritin (PMID: 6817879). The original antibody binds human ferritin with a binding affinity of Kd= 5.1nM (EP2193147). The thiolated version of this antibody was conjugated to maleimide-activated polylactide nanoparticles (NPs) to generate immunonanoparticles, which may carry drugs to desired overexpressing antigen cells potentially leading to improved drug therapy and reduced systemic adverse effects (PMID: 19835957). Preclinical studies showed that the immunoconjugate with 90Y has 98% stability over 7 days. A very good pancreatic adenocarcinoma tumor targeting was observed especially with the Bz-DTPA-AMB8LK (PMID: 17383579) |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |