Vector Labs Ab03947-3.3 Anti-CD70 [LD70], Mouse IgG2b, Fc Silent™, kappa (100 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: LD70
Heavy Chain Modification: Fc Silent™
Synonyms: TNFSF7; CD27L; CD27-L; CD27LG; CD27 ligand; CD70 antigen; Tumor necrosis factor ligand superfamily member 7
Amount: 100 μg
Application Codes Clone: block; ELISA
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: scFv
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This full-length, chimeric mouse antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds human CD70, a cytokine belonging to the tumor necrosis factor (TNF) ligand family, which acts as a ligand for TNFRSF27/CD27. It is a surface antigen present on activated T and B cells. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. CD70 is also identified as an emerging target in cancer immunotherapy.
Application Notes: This antibody block the binding of CD70 to CD21. This blocking effect was tested using the scFv version and it was reported that it was capable of blocking the binding of recombinant CD70-Fc to CD21 coated on ELISA plates. This antibody was also reported to have inhibitory effect on the growth of breast cancer cells in vitro. The in vivo inhibitory activity of this antibody was tested in mice infected with breast cancer cells MDA-MB-231. It was further reported that this antibody could inhibit tumor growth in vivo (CN109021106).

Product Class:	Purified
Clone ID:	LD70
Heavy Chain Modification:	Fc Silent™
Synonyms:	TNFSF7; CD27L; CD27-L; CD27LG; CD27 ligand; CD70 antigen; Tumor necrosis factor ligand superfamily member 7
Amount:	100 μg
Application Codes Clone:	block; ELISA
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	scFv
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This full-length, chimeric mouse antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds human CD70, a cytokine belonging to the tumor necrosis factor (TNF) ligand family, which acts as a ligand for TNFRSF27/CD27. It is a surface antigen present on activated T and B cells. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. CD70 is also identified as an emerging target in cancer immunotherapy.
Application Notes:	This antibody block the binding of CD70 to CD21. This blocking effect was tested using the scFv version and it was reported that it was capable of blocking the binding of recombinant CD70-Fc to CD21 coated on ELISA plates. This antibody was also reported to have inhibitory effect on the growth of breast cancer cells in vitro. The in vivo inhibitory activity of this antibody was tested in mice infected with breast cancer cells MDA-MB-231. It was further reported that this antibody could inhibit tumor growth in vivo (CN109021106).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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