Vector Labs Ab03951-10.3 Anti-TGF beta [1D11.16.8], Human IgG1, Fc Silent™, kappa (100 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: 1D11.16.8
Heavy Chain Modification: Fc Silent™
Synonyms: TGF-β; TGFβ; TGFB1; TGFB2; TGFB3; TGF-B1; TGF-B2; TGF-B3; TGF beta 1; TGF beta 2; TGF beta 3; CED; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; transforming growth factor; transforming growth factor beta; 1D11.16; 1D11
Amount: 100 μg
Application Codes Clone: neutralize; WB; IP; IHC; IHC-P; functional assay
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody recognizes and binds human, mouse, rat, cow, dog, hamster, monkey and other non-human primate transforming growth factor (TGF) beta 1, 2 and 3. TGF beta is a multifunctional cytokine that exists as five isoforms (TGF beta 1-5) that share 70-80% homology with each other. These proteins are produced by many cell types and function as growth and differentiation factors.
Application Notes: This antibody was able to neutralize the biological activity of both TGF-beta 1 and beta 2 in vitro. This antibody could detect the dimeric form of TGF-beta 2 in western blots. This antibody was also reported to immunoprecipitate [125I]-TGF-beta 2 (PMID: 2537357). This antibody is also able to neutralize the growth promoting actions of TGF-B1 and B2 in the NRK proliferation assay and TGF-B induced alkaline phosphatase production in an assay using the ROS 17.2.8 osteosarcoma cell line (US5571714). This antibody was used for detection of TGF-β production in vivo in spleens sections of L. donovani-infected hamsters using immunohistochemistry (PMID: 9488418). This antibody was also used for the immunohistochemical analysis of FFPE human renal biopsy specimens for presence of TGF-beta (PMID: 10515378).

Product Class:	Purified
Clone ID:	1D11.16.8
Heavy Chain Modification:	Fc Silent™
Synonyms:	TGF-β; TGFβ; TGFB1; TGFB2; TGFB3; TGF-B1; TGF-B2; TGF-B3; TGF beta 1; TGF beta 2; TGF beta 3; CED; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; transforming growth factor; transforming growth factor beta; 1D11.16; 1D11
Amount:	100 μg
Application Codes Clone:	neutralize; WB; IP; IHC; IHC-P; functional assay
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody recognizes and binds human, mouse, rat, cow, dog, hamster, monkey and other non-human primate transforming growth factor (TGF) beta 1, 2 and 3. TGF beta is a multifunctional cytokine that exists as five isoforms (TGF beta 1-5) that share 70-80% homology with each other. These proteins are produced by many cell types and function as growth and differentiation factors.
Application Notes:	This antibody was able to neutralize the biological activity of both TGF-beta 1 and beta 2 in vitro. This antibody could detect the dimeric form of TGF-beta 2 in western blots. This antibody was also reported to immunoprecipitate [125I]-TGF-beta 2 (PMID: 2537357). This antibody is also able to neutralize the growth promoting actions of TGF-B1 and B2 in the NRK proliferation assay and TGF-B induced alkaline phosphatase production in an assay using the ROS 17.2.8 osteosarcoma cell line (US5571714). This antibody was used for detection of TGF-β production in vivo in spleens sections of L. donovani-infected hamsters using immunohistochemistry (PMID: 9488418). This antibody was also used for the immunohistochemical analysis of FFPE human renal biopsy specimens for presence of TGF-beta (PMID: 10515378).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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