Mfg Part Number
Ab03956-10.3
Vector Labs Ab03956-10.3 Anti-Factor VIII [YK3.3.38], Human IgG1, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was isolated from a scFv phage display library generated using the peripheral blood lymphocytes from a hemophilia patient.
$570.70
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | YK3.3.38 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | AHF; FVIII; Factor 8; anti-hemophilic factor; Coagulation factor VIII; procoagulant component |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for an epitope 'RPLYSRRLPKGVKHLKDFPILPGEI' (residues 389 to 510) in the A2 domain of the human factor VIII, a glycoprotein involved in blood coagulation. Factor VIII acts as a cofactor for factor IXa which converts factor X to the activated form Xa in the presence of calcium and phospholipids. Defects in the F8 gene, which encodes Factor VIII, result in the coagulation disorder hemophilia A. |
| Application Notes: | This antibody can bind human blood coagulation factor VIII in an ELISA. It was reported that this antibody potently inhibits the coagulation activity of factor VIII in vitro at a concentration of 10 ng/ml. This antibody does not inactivate FVIII bound with vWF but inactivated FVIII free from vWF (US20040120951). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |