Mfg Part Number
Ab03957-10.3
Vector Labs Ab03957-10.3 Anti-Factor VIII A2 domain [BOIIB2], Human IgG1, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was generated from the peripheral blood lymphocytes obtained from a hemophilia patient.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | BOIIB2 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | AHF; FVIII; A2 domain; Factor 8; anti-hemophilic factor; Coagulation factor VIII; procoagulant component; NB11B2 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; inhibit |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds the A2 domain of the human factor VIII, a glycoprotein involved in blood coagulation. Factor VIII acts as a cofactor for factor IXa which converts factor X to the activated form Xa in the presence of calcium and phospholipids. Defects in the F8 gene, which encodes Factor VIII, result in the coagulation disorder hemophilia A. |
| Application Notes: | The binding specificity and epitope characterization of this antibody was determined using ELISA. The ability of this antibody inhibit factor VIII function in vitro was studied using a chromogenic functional assay. It was reported that this antibody inhibited the conversion of factor X to factor Xa at concentration of 0.1 μg/ml. It was found that this antibody inhibits thrombin production using both the intrinsic and extrinsic pathway of coagulation (US20080206254). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |