Mfg Part Number
Ab03958-10.0
Vector Labs Ab03958-10.0 Anti-RSPO2 [h130M23-H1L2], Human IgG1, kappa (100 μg)
Quick Overview
The antibody is the humanized version of the murine 130M23.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | h130M23-H1L2 |
| Synonyms: | hRspo2; R-spondin-2; Roof plate-specific spondin-2 |
| Amount: | 100 μg |
| Application Codes Clone: | SPR; blocking; in vitro; in vivo |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | The antibody specifically reacts with human and mouse RSPO2. |
| Application Notes: | The antibody was shown to completely block β-catenin signaling, demonstrating it is a specific inhibitor of RSPO2. The antibody blocked soluble RSPO2 binding to LGR5. The antibody had a binding affinity for human RSPO2 of 0.14 nM and mouse RSPO2 of 0.35 nM. The antibody demonstrated strong anti-tumor growth activity in combination with gemcitabine in a pancreatic xenograft model and inhibition of pancreatic tumor growth in vivo as a single agent and in combination with additional therapeutic agents. The humanized version of the antibody was produced. The humanized version had a binding affinity for human RSPO2 of 0.13 nM (US8802097B2). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |