Mfg Part Number
Ab03984-10.0
Vector Labs Ab03984-10.0 Anti-Islet beta cells autoantigen [H116], Human IgG1, kappa (100 μg)
Quick Overview
The original antibody was generated from a B lymphocyte islet-infiltrate of a diabetes-resistant but insulitis-prone (8.3-NODxNOR) F1 mouse.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | H116 |
| Synonyms: | Unknown islet β-cells autoantigen; unknown intraislets autoantigen |
| Amount: | 100 μg |
| Application Codes Clone: | IF |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 18433871 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for an unknown autoantigen (still under investigation, as of 2016), expressed in islet beta cells (also referred to as intraislet). |
| Application Notes: | This antibody recognizes antigenic determinants selectively expressed in islet β-cells of the pancreas, as determined by immunofluorescence (IF) staining; its staining pattern mimics the pattern obtained with anti-insulin antibodies. Furthermore, this antibody was shown to be cross-reactive with stomach and kidney cryosections of NOD.RAG-2−/− mice (Carrillo et al., 2005; PMID: 15616012). This antibody was also used for tissue immunostaining of pancreatic cryosections from NOD.RAG-2−/− mice (Carrascal et al., 2016; PMID: 26639224). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |