Mfg Part Number
Ab03991-10.0
Vector Labs Ab03991-10.0 Anti-Gamma Delta TCR [B1.1], Human IgG1, kappa (100 μg)
Quick Overview
Antigen-specific T cell blasts to poly-18, a polypeptide antigen of defined sequence and conformation, were generated from lymph nodes of antigen primed BALB/cCr mice. These blasts were fused with the BW5147 thymoma to obtain anti-poly-18-reactive T cell hybridomas from which the original antibody was generated.
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| Product Class: | Purified |
|---|---|
| Clone ID: | B1.1 |
| Synonyms: | TCR γδ; γδ TCR; TCR GD; GD TCR; TCRg/d; T-cell surface glycoprotein CD3 delta chain; CD3D; T3D; T-cell receptor T3 delta chain; T-cell surface glycoprotein CD3 gamma chain; CD3G; T-cell receptor T3 gamma chain; CD3g; T3G; B1 |
| Amount: | 100 μg |
| Application Codes Clone: | FC; block; IHC; IF; functional assay |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for the human TCR delta and gamma chains. The T-cell receptor (TCR) is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. On activation through antigen presenting cells (APCs), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. TCR part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. |
| Application Notes: | This antibody can be used for the flow cytometric analysis of human peripheral blood cells (PMID: 12121897; 23447017; 25777993; 28223321). This antibody was used to block human γδ T cell receptor and prevent the human anti-porcine γδ T cell response (PMID: 11502983; 28713391). This antibody was also used to block the γδ T cell receptors in in-vitro tumor-killing assays (PMID: 21633088). This antibody was used for the immunohistochemical analysis of frozen tissue samples of parapsoriasis, mycosis fungoides and inflammatory dermatoses (PMID: 21479436). This antibody was also used for the immunohistochemical and indirect immunofluorescence staining of γδ T cells in breast cancer and normal tissues (PMID: 23959855). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |