Mfg Part Number
Ab04090-10.0
Vector Labs Ab04090-10.0 Anti-MMAE [AbAb-MMAE01], Human IgG1, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing BALB/c mice with MMAE small molecule antigen in equal volume of complete Freund's adjuvant.
$570.70
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | AbAb-MMAE01 |
| Synonyms: | Monomethylauristatin E; Vedotin; USAN; monomethyl auristatin F; NMAF; auristatins |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds auristatin (MMAE, MMAF) which is a cytotoxic drug (payload) employed in the ADC field. Monomethyl auristatin E (MMAE, vedotin) is a very potent antimitotic agent that inhibits cell division by blocking the polymerization of tubulin. The family of auristatins are synthetic analogues of the antineoplastic natural product Dolastatin 10, ultrapotent cytotoxic microtubule inhibitors that are clinically used as payloads in antibody-drug conjugates. As an antibody-drug conjugate or ADC, MMAE is linked to a monoclonal antibody (mAb) that recognizes a specific marker expression in cancer cells and directs MMAE to a specific, targeted cancer cell. |
| Application Notes: | This antibody shows the good binding activity with TROP2-ADC in a sandwich ELISA, therefore it can be used as a detection reagent for MMAE-conjugated antibody drugs (CN112457406). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |