Mfg Part Number
Ab04091-1.1
Vector Labs Ab04091-1.1 Anti-MMAE [04CT2.2.3], Mouse IgG1, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing BALB/c mice with MMAE-cysteine-KLH conjugate in equal volume of complete Freund's adjuvant.
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| Product Class: | Purified |
|---|---|
| Clone ID: | 04CT2.2.3 |
| Synonyms: | Monomethylauristatin E; Vedotin; USAN; monomethyl auristatin F; NMAF; auristatins |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds auristatin (MMAE, MMAF) which is a cytotoxic drug (payload) employed in the ADC field. Monomethyl auristatin E (MMAE, vedotin) is a very potent antimitotic agent that inhibits cell division by blocking the polymerization of tubulin. The family of auristatins are synthetic analogues of the antineoplastic natural product Dolastatin 10, ultrapotent cytotoxic microtubule inhibitors that are clinically used as payloads in antibody-drug conjugates. As an antibody-drug conjugate or ADC, MMAE is linked to a monoclonal antibody (mAb) that recognizes a specific marker expression in cancer cells and directs MMAE to a specific, targeted cancer cell. |
| Application Notes: | The binding activity of this antibody towards MMAE-BSA conjugate was determined using ELISA. This antibody is also capable of binding to MMAE-conjugated antibody drugs and can be used for their detection in cancer research (CN114181307). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |