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Mfg Part Number

Ab04092-10.0

Vector Labs Ab04092-10.0 Anti-SN-38 [1H3-1], Human IgG1, lambda (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing BALB/c mice with SN38-BSA conjugate.

$570.70

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Description

Product Class: Purified
Clone ID: 1H3-1
Synonyms: SN38; Topotecan; Camptothecin; CPT; 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin; 10-Hydroxy-7-ethylcamptothecin; 7-Ethyl-10-hydroxy-20(S)-camptothecin; 7-Ethyl-10-hydroxycamptothecin; NK 012; NK-012
Amount: 100 μg
Application Codes Clone: ELISA; SPR
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2b
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds SN-38, which is an active metabolite of irinotecan (a semisynthetic analog of camptothecin - a topoisomerase I inhibitor) generated by carboxyl esterases through hydrolysis. SN-38 has potential antineoplastic activity. It binds and inhibits topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication, and apoptosis. In vitro cytotoxicity assays have shown that SN-38 is 1,000-times more cytotoxic than irinotecan against various cancerous cells. SN-38 is commonly used as a cytotoxic drug payload in the ADC field.
Application Notes: The binding reactivity of this antibody to SN38-BSA conjugate was determined using ELISA. The binding affinity of this antibody to SN38-KLH conjugate was determined using surface plasmon resonance (SPR). It was reported that this antibody binds SN38-KLH conjugate with a binding affinity of Kd=3.06 nM (CN115197323).

Product Class:	Purified
Clone ID:	1H3-1
Synonyms:	SN38; Topotecan; Camptothecin; CPT; 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin; 10-Hydroxy-7-ethylcamptothecin; 7-Ethyl-10-hydroxy-20(S)-camptothecin; 7-Ethyl-10-hydroxycamptothecin; NK 012; NK-012
Amount:	100 μg
Application Codes Clone:	ELISA; SPR
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2b
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds SN-38, which is an active metabolite of irinotecan (a semisynthetic analog of camptothecin - a topoisomerase I inhibitor) generated by carboxyl esterases through hydrolysis. SN-38 has potential antineoplastic activity. It binds and inhibits topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication, and apoptosis. In vitro cytotoxicity assays have shown that SN-38 is 1,000-times more cytotoxic than irinotecan against various cancerous cells. SN-38 is commonly used as a cytotoxic drug payload in the ADC field.
Application Notes:	The binding reactivity of this antibody to SN38-BSA conjugate was determined using ELISA. The binding affinity of this antibody to SN38-KLH conjugate was determined using surface plasmon resonance (SPR). It was reported that this antibody binds SN38-KLH conjugate with a binding affinity of Kd=3.06 nM (CN115197323).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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