Mfg Part Number
Ab04096-3.0
Vector Labs Ab04096-3.0 Anti-DR4 [T1014G03 ], Mouse IgG2b, lambda (100 μg)
Quick Overview
The original antibody was isolated from a human scFv library by panning against human TR4 fusion protein. Later on the scFv version of this antibody was converted to human IgG1 version for carrying out further studies.
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| Product Class: | Purified |
|---|---|
| Clone ID: | T1014G03 |
| Synonyms: | CD261; TR4; TNFRSF10A; APO2; TRAILR1; Tumor necrosis factor receptor superfamily member 10A; Death receptor 4; TNF-related apoptosis-inducing ligand receptor 1 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; in vivo |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds human CD261 (TR4 or TRAILR1 or TNFRSF10A). This protein acts as a receptor for the cytotoxic ligand TNFSF10/TRAIL and transduces cell death signal and induces cell apoptosis. |
| Application Notes: | The binding specificity of this antibody to human TR4 (CD126) fusion protein was determined using ELISA. This antibody does not cross react with other proteins like TR7, TR5, TR10 and BLyS. It was reported that the scFv version of the antibody binds human TR4 fusion protein with a binding affinity of Kd= 5.54 × 10^(-10) nM. It was also reported that when administered with in vivo Topotecan, this antibody was capable of retarding the growth of tumor cells in nude mice (US7064189). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |