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Mfg Part Number

Ab04117-21.0

Vector Labs Ab04117-21.0 Anti-HCV core protein [19D9D6], Mouse IgM, kappa (50 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing BALB/c JYco mice with a truncated recombinant protein corresponding to the immunodominant region (residues 1–120) of the Hepatitis C Virus (HCV) purified nucleocapsid protein (HCV C120-GST fusion protein).

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Description

Product Class: Purified
Clone ID: 19D9D6
Synonyms: Hepatitis C virus core protein
Amount: 50 μg
Application Codes Clone: ELISA
Shipping Temperature: Wet Ice
Origin Pub PMID: 12574359
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for the protein sequence QIVGGVYLL located at residues 29-37 of the HCV core protein. Hepatitis C virus (HCV) is the primary cause of hepatitis transmitted through blood transfusion. It is an enveloped virus that contains a single-stranded, positive-sense RNA genome of approximately 9600 nucleosides. This genome encodes a polyprotein of 3011 amino acids, which undergoes post-translational cleavage to form both structural and nonstructural proteins. Among the structural proteins, the core protein is derived from the amino terminus of the viral polypeptide (amino acids 1-191).
Application Notes: This antibody was used for an indirect ELISA to detect anti-HCV core response in human sera, an ELISA competition assays to assess the interaction between monoclonal antibodies and anticore human sera, a sandwich ELISA for the capture and detection of viral core antigen in chronic HCV patient sera, and a sandwich ELISA for the detection of recombinant core protein (Jolivet-Reynaud et al., 1998; PMID: 9829633). The crystal structure of the Fab version of this antibody was solved in complex with an HCV core protein-derived peptide (residues 13-40), revealing the hydrophobic nature of the recognized epitope (Ménez et al., 2003; PMID: 12574359).

Product Class:	Purified
Clone ID:	19D9D6
Synonyms:	Hepatitis C virus core protein
Amount:	50 μg
Application Codes Clone:	ELISA
Shipping Temperature:	Wet Ice
Origin Pub PMID:	12574359
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for the protein sequence QIVGGVYLL located at residues 29-37 of the HCV core protein. Hepatitis C virus (HCV) is the primary cause of hepatitis transmitted through blood transfusion. It is an enveloped virus that contains a single-stranded, positive-sense RNA genome of approximately 9600 nucleosides. This genome encodes a polyprotein of 3011 amino acids, which undergoes post-translational cleavage to form both structural and nonstructural proteins. Among the structural proteins, the core protein is derived from the amino terminus of the viral polypeptide (amino acids 1-191).
Application Notes:	This antibody was used for an indirect ELISA to detect anti-HCV core response in human sera, an ELISA competition assays to assess the interaction between monoclonal antibodies and anticore human sera, a sandwich ELISA for the capture and detection of viral core antigen in chronic HCV patient sera, and a sandwich ELISA for the detection of recombinant core protein (Jolivet-Reynaud et al., 1998; PMID: 9829633). The crystal structure of the Fab version of this antibody was solved in complex with an HCV core protein-derived peptide (residues 13-40), revealing the hydrophobic nature of the recognized epitope (Ménez et al., 2003; PMID: 12574359).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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