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Mfg Part Number

Ab04138-10.3

Vector Labs Ab04138-10.3 Anti-RANK-L [14F3], Human IgG1, Fc Silent™, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing CB6 fl mice with human RANKL protein.

$570.70

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Description

Product Class: Purified
Clone ID: 14F3
Heavy Chain Modification: Fc Silent™
Synonyms: CD254; TRANCE; RANKL; ODF; OPGL; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; Osteoprotegerin ligand; Receptor activator of nuclear factor kappa-B ligand; TNF-related activation-induced cytokine
Amount: 100 μg
Application Codes Clone: ELISA; Inhibition
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2a
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: The antibody is specific for human-RANK-L. It does not recognize murine RANK-L. RANKL is a tumor necrosis factor (TNF)-related protein that binds to, and activates, the TNF receptor (TNFR)-related protein Receptor Activator of NF-kB (RANK). RANKL acts as the key cytokine that regulates osteoclast differentiation and activation during normal bone remodeling and during disease
Application Notes: The specificity of the original version of the antibody was confirmed by ELISA analysis (IC50 = 2 nM). The antibody specifically inhibits the functional activity of RANKL induction of DC maturation. The antibody could strongly inhibit the interaction between human RANKL and its receptor RANK in human monocytes. The inhibition led to antagonism of RANKL-mediated DC maturation and osteoclast development and function (US20040213788).

Product Class:	Purified
Clone ID:	14F3
Heavy Chain Modification:	Fc Silent™
Synonyms:	CD254; TRANCE; RANKL; ODF; OPGL; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; Osteoprotegerin ligand; Receptor activator of nuclear factor kappa-B ligand; TNF-related activation-induced cytokine
Amount:	100 μg
Application Codes Clone:	ELISA; Inhibition
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2a
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	The antibody is specific for human-RANK-L. It does not recognize murine RANK-L. RANKL is a tumor necrosis factor (TNF)-related protein that binds to, and activates, the TNF receptor (TNFR)-related protein Receptor Activator of NF-kB (RANK). RANKL acts as the key cytokine that regulates osteoclast differentiation and activation during normal bone remodeling and during disease
Application Notes:	The specificity of the original version of the antibody was confirmed by ELISA analysis (IC50 = 2 nM). The antibody specifically inhibits the functional activity of RANKL induction of DC maturation. The antibody could strongly inhibit the interaction between human RANKL and its receptor RANK in human monocytes. The inhibition led to antagonism of RANKL-mediated DC maturation and osteoclast development and function (US20040213788).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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