Mfg Part Number
Ab04141-10.0
Vector Labs Ab04141-10.0 Anti-RANK-L [2G8], Human IgG1, kappa (100 μg)
Quick Overview
The original antibody was generated by panning a fully human Naive combined antibody library against RANKL.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | 2G8 |
| Synonyms: | CD254; TRANCE; RANKL; ODF; OPGL; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; Osteoprotegerin ligand; Receptor activator of nuclear factor kappa-B ligand; TNF-related activation-induced cytokine |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; neutralizing |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | The antibody is specific for human-RANK-L. RANKL is a tumor necrosis factor (TNF)-related protein that binds to, and activates, the TNF receptor (TNFR)-related protein Receptor Activator of NF-kB (RANK). RANKL acts as the key cytokine that regulates osteoclast differentiation and activation during normal bone remodeling and during disease. |
| Application Notes: | The affinity of the original format of the antibody was determined by Scatchard analysis; the results showed that the affinity of the antibody reached 3.2X10E-9. The specificity of the Fab version of the antibody was confirmed by ELISA analysis. The Fab fragment had a good neutralizing effect when tested in an antagonistic RANKL neutralization ability test (WO2009105934A1). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |