Mfg Part Number
Ab04143-23.0
Vector Labs Ab04143-23.0 Anti-hepsin [Mab55], Rabbit IgG, lambda (100 μg)
Quick Overview
The antibody is the humanized version of the murine Mab 2.7.35.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | Mab55 |
| Synonyms: | Serine protease hepsin; EC:3.4.21.106; Transmembrane protease serine 1 |
| Amount: | 100 μg |
| Application Codes Clone: | FC; Inhibition; Crystallograpy; SPR |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | Fab |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody is specific for hepsin and cross-reacts with cynomolgus hepsin. Human hepsin is a Type II serine transmembrane protease and belongs to the trypsin family of serine proteases. Hepsin was identified by homology screening of a human liver cDNA library in 1988. It plays an important role in cell growth and maintenance of cell line morphology |
| Application Notes: | The crystal structure of the Fab fragment of the antibody in complex with hHepsin was determined. The binding affinity of the Fab fragments to hHepsin was measured by surface plasmon resonance (Kd= 39.8 nM). The original antibody could inhibit hepsin. The original antibody could detect hepsin expressed in HEK293 cells by flow cytometry and confocal microscopy analysis (WO2011161189A1). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |